Officers are currently dealing with a one vehicle road traffic collision on the A5086 near Eaglesfield.
Police were contacted shortly after 11.30am today (5 February).
The road is currently closed between Oakhurst roundabout and Deanscales.
Motorists are advised to avoid the area and use alternative routes.
Visit the traffic link map at www.cumbria.police.uk/traffic-link-map to keep up to date with the latest situation on the roads.